| Cover | | Date
 | Title  Album | Points
 | US peak | UK peak | US R&B peak | Comment |
|---|
 | 1. | 1991 | | 66
 | 11 US | | 23 R&B | written by 2Pac (as Tupac Shakur) & Deion "Big D" Evans |
| 2. | 1993 | | 6
 | 87 US | | 82 R&B | featuring Thug Life written by 2Pac (as Tupac Shakur)  |
 | 3. | 07/1993 | | 87
 | 11 US | | 5 R&B | featuring Digital Underground written by 2Pac , Shock G, Larry Troutman, Shirley Murdock & Money-B |
 | 4. | 07/1993 | | 80
 | 12 US | | 7 R&B | B side to I Get Around written by 2Pac (as Tupac Shakur)  |
| 5. | 1995 | | 1
 | | | 70 R&B | [R&B chart position is for R&B airplay charts] |
 | 6. | 03/1995 | | 129
 | 9 US | 96 UK | 3 R&B | [artist #5 hit] written by Bruce Hawes, Joe Jefferson (as Joseph Jefferson), Tony Pizarro, Joe Sample, 2Pac (as Tupac Shakur) & Charles Simmons |
| 7. | 06/1995 | | 61
 | 13 US | | | B side to Dear Mama |
 | 8. | 07/1995 | | 22
 | 44 US | | 21 R&B | written by 2Pac (as Tupac Shakur) , Shock G (as Gregory Jacobs), Stretch (as Randy Walker), E. Baker & Stevie Wonder |
 | 9. | 09/1995 | | 11
 | 68 US | | 35 R&B | written by 2Pac (as Tupac Shakur) , Roger (as Roger Troutman), Larry Troutman, Shirley Murdock, George Clinton (as George Clinton Jr.), Garry Shider, D. Spradley & Easy Mo Bee (as Osten Harvey Jr.) |
| 10. | 1996 | | 2
 | | | 46 R&B | featuring Snoop Dogg [R&B chart position is for R&B airplay charts] written by 2Pac (as Tupac Shakur) , Snoop Dogg (as Calvin Broadus) & Daz Dillinger (as Delmar Arnaud) |
|
 | 11. | 04/1996 | | 280
 | ✫1 US | 6 UK | ✫1 R&B | [artist #1 hit] featuring Dr. Dre & Roger Troutman
[Rolling Stone 500 Greatest Songs #346] charted as How Do U Want It / California Love in US Hot 100 charts written by Joe Cocker, Woodrow Cunningham, Norman Durham, Mikel Hooks, Ronald Hudson, Christopher Stainton, Larry Troutman, Roger (as Roger Troutman), James Anderson & 2Pac (as Tupac Shakur)  |
 | 12. | 06/1996 | | 241
 | ✫1 US | 17 UK | ✫1 R&B | [artist #2 hit] featuring K-Ci and JoJo B side to California Love in the US ; charted as How Do U Want It / California Love in US Hot 100 charts written by 2Pac (as Tupac Shakur) , Johnny Jackson, Bruce Fisher, Leon Ware, Stanley Richardson & Quincy Jones |
 | 13. | 11/1996 | | 56
 | | 13 UK | 18 R&B | featuring K-Ci & JoJo [R&B chart position is for R&B airplay charts] written by Daz Dillinger (as Delmar Arnaud), Etterlene Jordan, 2Pac (as Tupac Shakur) & Danny Steward |
| 14. | 02/1997 | | 12
 | 81 US | 172 UK | 57 R&B | featuring The Notorious B.I.G., Radio, Dramacydal & Stretch written by 2Pac (as Tupac Shakur) , The Notorious B.I.G. (as Christopher Wallace), Dramacydal & Stretch (as Randy Walker) |
| 15. | 04/1997 | | 55
 | | 10 UK | | as Makaveli written by 2Pac (as Makaveli)  |
| 16. | 04/1997 | | 43
 | | 16 UK | | featuring Snoop Dogg written by 2Pac (as Tupac Shakur) & Snoop Dogg (as Calvin Broadus) |
 | 17. | 08/1997 | | 47
 | | 15 UK | 34 R&B | as Makaveli [R&B chart position is for R&B airplay charts] written by Aaron Hall, Reginald Moore, 2Pac (as Tupac Shakur) , Demetrius Shipp, Danny Steward, K-Ci (as Cedric Hailey) & JoJo (as JoJo Hailey) |
 | 18. | 12/1997 | | 48
 | 67 US | 21 UK | 14 R&B | featuring Maxee written by 2Pac (as Tupac Shakur) , D.K. McDowell, Larry Troutman, Lawrence Goodman & Roger (as Roger Troutman) |
| 19. | 02/1998 | | 19
 | | 43 UK | 12 R&B | as Makaveli [R&B chart position is for R&B airplay charts] written by Rufus Cooper, Katari Cox, Yafeu Fula, Joseph Paquette, 2Pac (as Tupac Shakur) , Bruce Washington & Tyrone Wrice |
 | 20. | 03/1998 | | 101
 | 21 US | 12 UK | 10 R&B | featuring Eric Williams of BLACKstreet written by Robert Caldwell, Kenneth Karlin, Alfons Kettner, Soulshock (as Carsten Schack) & 2Pac (as Tupac Shakur)  |
| 21. | 07/1998 | | 45
 | | 15 UK | 57 R&B | [rm] written by 2Pac (as Tupac Shakur) , The Notorious B.I.G. (as Christopher Wallace), Dramacydal & Stretch (as Randy Walker) |
| 22. | 11/1998 | | 41
 | | 17 UK | | written by 2Pac (as Tupac Shakur)  |
 | 23. | 12/1998 | | 140
 | 32 US | 3 UK | 12 R&B | [artist #4 hit] written by Deon Evans, Bruce Hornsby & 2Pac (as Tupac Shakur)  |
| 24. | 1999 | | 2
 | | | 53 R&B | featuring Yaki Kadafi |
| 25. | 07/1999 | | 24
 | | 27 UK | | |
| 26. | 2000 | | 1
 | | | 56 R&B | |
| 27. | 2000 | | 1
 | | | 73 R&B | [R&B chart position is for R&B airplay charts] written by 2Pac (as Tupac Shakur)  |
 | 28. | 02/2000 | | 10
 | 72 US | | 36 R&B | featuring The Outlawz written by 2Pac (as Tupac Shakur)  |
 | 29. | 04/2001 | | 115
 | 52 US | 4 UK | 21 R&B | written by 2Pac (as Tupac Shakur)  |
 | 30. | 11/2001 | | 32
 | | 21 UK | 64 R&B | written by 2Pac (as Tupac Shakur) & Michael Jackson |
 | 31. | 12/2002 | | 91
 | 19 US | 24 UK | 10 R&B | featuring Nas written by 2Pac (as Tupac Shakur)  |
| 32. | 04/2003 | | 17
 | 69 US | | 31 R&B | featuring Trick Daddy written by 2Pac (as Tupac Shakur) & F. Ross |
 | 33. | 10/2003 | | 110
 | 19 US | 17 UK | 11 R&B | as TUPac featuring The Notorious B.I.G. written by 2Pac (as Tupac Shakur) , Eminem (as Mathers Mathers), The Notorious B.I.G. (as Christopher Wallace), Edgar Winter, Luis Resto & Easy Mo Bee (as Osten Harvey) |
 | 34. | 02/2004 | | 10
 | 80 US | 134 UK | 51 R&B | as TUPac with Eminem featuring The Outlawz written by 2Pac (as Tupac Shakur) & Eminem (as Mathers Mathers) |
 | 35. | 01/2005 | | 6
 | 98 US | | 55 R&B | featuring Nate Dogg [Amaru 003970] written by 2Pac (as Tupac Shakur)  |
| 36. | 01/2005 | | 2
 | | 158 UK | | as TUPac featuring The Notorious B.I.G. [R] written by 2Pac (as Tupac Shakur) , Eminem (as Mathers Mathers), The Notorious B.I.G. (as Christopher Wallace), Edgar Winter, Luis Resto & Easy Mo Bee (as Osten Harvey) |
 | 37. | 07/2005 | | 146
 | | ✫1 UK | | [artist #3 hit] featuring Elton John written by 2Pac (as Tupac Shakur) , Elton John (sample) & Bernie Taupin (sample) |
| 38. | 11/2006 | | 3
 | 111 US | | 91 R&B | featuring Bone Thugs-n-Harmony [album cut] written by 2Pac (as Tupac Shakur)  |
 | 39. | 12/2006 | | 35
 | 119 US | 21 UK | 81 R&B | featuring Ashanti & T.I. [album cut] written by 2Pac (as Tupac Shakur) , T.I. (as Clifford Harris) & Ashanti (as Ashanti Douglas) |
| 40. | 04/2012 | | 2
 | | 196 UK | | featuring Talent written by Deon Evans, Bruce Hornsby & 2Pac (as Tupac Shakur)  |
| Top 100 hits | 21 | 20 | 32 | |
| Top 40 hits | 11 | 18 | 19 | |
| Top 10 hits | 3 | 5 | 7 | |
| ✫ #1 hits | 2 | 1 | 2 | |
| US | UK | R&B | |